RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
miR-378a-3p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
dual-lucimmunofluorescenceerase reporter assay; hydroxyproline assay etc.
Target
NA
Pathway
NF-KAPPA B SIGNALING PATHWAY; HEDGEHOG SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
Year
2016
Function
Toll like receptor 2 knock-out attenuates carbon tetrachloride (ccl4)-induced liver fibrosis by downregulating mapk and nf-kb signaling pathways.